NICE recommends Takeda’s HAE treatment, Takhzyro for use on NHS

A final appraisal document has been published indicating the subcutaneous injection as an option for preventing recurrent attacks of hereditary angioedema (HAE) in patients aged 12 and older, meaning that those eligible can now receive the innovative treatment. Although patients will only receive the drug if they are eligible for preventive C1-esterase inhibitor (C1-INH) treatment

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NICE emphasises requirement for more cannabis related research

NICE has published its new draft recommendations on the use of cannabis-based medicinal products, following a comprehensive evaluation of their clinical and cost-effectiveness. The organisation says that the recommendation of fast-tracked guidance follows the re-classification of these products last year to allow specialist doctors to ‘prescribe them where the clinical needs of patients cannot be

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NICE presents long anticipated review of methodologies

NICE has unveiled a long-awaited review of its health technology evaluation methodologies, although a re-think on its core ‘QALY threshold’ approach won’t be included. England’s cost effectiveness watchdog recently celebrated its 20th anniversary and has often had a fractious relationship with the pharma industry over those years, especially when drugs have been rejected because of

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Novartis Breast Cancer Treatment gains NICE Recommendation

Novartis announces Ribociclib has been recommended by the NICE for use on the NHS in combination with fulvestrant, where exemestane plus everolimus is the most appropriate alternative, for treating women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) locally advanced or metastatic breast cancer who have received prior endocrine therapy. Ribociclib in combination

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NICE Patisiran approval puts Alnylam back in hATTR running

NICE recommends use of Alnylam’s Patisiran, after issuing a preliminary ‘no’ back in December 2018. The treatment is for a progressive, life-threatening disease called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis), which until recently, was an area of significant unmet need in England. The drug will now provide eligible patients suffering from the disease with a treatment

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NICE approves Amgen’s leukaemia treatment

NICE announces the recommendation of Amgen’s blinatumomab for treating acute lymphoblastic leukaemia (ALL). The indication is for patients in first complete remission with minimal residual disease (MRD) activity of at least 0.1%. This decision to recommend the drug as a cost-effective use of NHS resources was made after the submission of new evidence from the

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Akcea obtains NICE approval for stage 1 or 2 polyneuropathy in adult patients with hATTR

Akcea Therapeutics’ Inotersen has received recommendation from NICE, meaning the therapy will now be made available to NHS patients in England and Wales for the treatment of Stage 1 or Stage 2 polyneuropathy in adult patients with hereditary transthyretin amyloidosis (hATTR).  hATTR is a serious condition caused by “the abnormal formation of the TTR protein

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