NICE Recommends Gilead’s Harvoni

The National Institute for Health and Care Excellence (NICE) have announced draft guidelines recommending Gilead’s Harvoni for regulatory approval. If approved, the combination therapy (ledipasvir-sofosbuvir) will be available to treat NHS patients with hepatitis C in England and Wales. Specifically, the drug has been recommended for the treatment of adults with genotype 1 or 4

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Gilead’s Harvoni Approved by European Regulators

European regulators have granted regulatory approval to Gilead Sciences’ hepatitis C combination treatment, Harvoni. Harvoni combines Gilead’s Sovaldi (sofosbuvir), a nucleotide analogue polymerase inhibitor, with NS5A inhibitor, ledipasvir, for HCV genotype 1 and 4 infection. The approval from the European Commission comes a month after the US FDA granted approval for the drug. The approval

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Gilead Discontinues Development of Cicletanine

Dow Jones reported yesterday that Gilead Sciences have dropped the diuretic cicletanine after it failed to meet targets in a mid-stage clinical trial analysing the drug’s potential in high blood pressure. The Phase II, randomised, double-blind, placebo-controlled, multicenter, dose- ranging study was evaluating the efficacy, safety and tolerability of cicletanine in comparison to a placebo

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Boehringer Ingelheim and Gilead Sign Agreement for HIV Compound Rights

German corporation, Boehringer Ingelheim, and the Californian firm, Gilead Sciences, have entered into a licensing agreement, under which Boehringer Ingelheim has given Gilead exclusive worldwide rights for the research, development and commercialisation of its novel non-catalytic site integrase inhibitors for HIV. This includes the lead compound BI 224436, which has been evaluated in a Phase

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